For the performance degradation of interferences suppression due to the difference in amplitude and phase among channels, an anti-jamming technology based on channels equalization using space-time adaptive processing applied in navigation is proposed. First, the actual spatial steering vector of the desired signal is estimated by the reference signal and the array data without interference, and the ideal direction of arrival (DOA) of the desired signal is estimated by the DOA method proposed in this paper, then the ideal spatial steering vector is obtained. So the amplitude and phase error is got by the actual spatial steering vector and the ideal spatial steering vector. Finally, the array data is corrected with the amplitude and phase error matrix, and then is used to reject interferences. This method can improve the performance of interference suppression. Simulation results show the effectiveness and superiority of the proposed method.