With its high reliability and real-time characteristic, CAN-bus is widely used in such the sectors as industry control, electricity communication, navigation, spaceflight and so on. The methods of designing CAN-bus communication system based on TMS320F28335 and of how to design the software and hardware are described. The result has showed the use of embedded eCAN module in TMS320F28335 will make the design of circuit and software more easy and reliable.