Traditional methods of antenna phase center are the calculation of the phase center of single cutting plane, which is proper for antenna dispersion and in the condition of the different phase centers in different cutting planes. An antenna phase center calculation method based on multi-objective programming is proposed in this paper. By obtaining multiple cutting planes in the main lobe, the calculation of antenna phase center is changed into the optimal value of multi-objective programming. Compared with traditional methods, the proposed method is not only fit for the phase center of single plane, but also fit for the phase center of the antenna main lobe. A circularly polarized antenna is simulated using HFSS and the proposed method is used to calculate the phase center. The validity of this method is approved by the calculated results