As one of the key project in our country, the integrated ground-air-space information network will be the strategic infrastructure and technology in the coming information times. As the development of cross-border electronic commerce, smart home and intelligence air manages, the necessary on the development of space-based internet of things is presented, so it is significant to combine the building of integrated ground-air-space information network project with space-based internet of things applications. This paper focus on the research of space-based internet of things applications based on integrated ground-air-space information network, includes reference model, network architecture, software system and protocols architecture, and lay the foundation to build the integrated ground-air-space information network project.