Air navigation is air activities guiding aircraft from one point to another point on time, which is by reference to the surface of globe. Every flight activity needs air navigation. The area of hills and basin is very vast as important topographic features of eastern and western part of our country. The exclusive geographical features and meteorological characteristics have great influence on air activities especially on air navigation. The paper analyzes the geographical features and meteorological characteristics of hills and basin. The method of air navigation is summarized on the hills and basin. The conclusion has important theoretical value on searching navigation problem, which also has practical significance to guide flying practice.