First introduces the reasons of positioning drift, drift will result in inaccurate positioning, analyzes the advantages and disadvantages of the methods such as Euclidean space distance, time sequence and correlation coefficient method. The theoretical basis of high-order difference are described, analyzed and deduced. According to the theory of high-order difference, a method based on the high-order difference method is proposed to determine whether there is a drift in position. According to the characteristics of subsequence of non differential speed test, the experimental results show that high-order difference method can effectively detect several positioning drift and judgment drift position, thereby reducing positioning drift, improve the accuracy of positioning data.