The Zynq-7000 series is based on Xilinx's fully programmable and extensible processing platform architecture. It is a SoC chip that integrates Cortex-A9 dual-core ARM and FPGA. During the development process of Zynq-7000 series chips using Vivado, IP cores in IP Catalog can be used. Users can also create their own IP cores for personalized and flexible use. The paper briefly introduces the functions of Zynq-7000 series chips, discusses the working principle and characteristics of 1553B interface bus, and according to the characteristics and protocols of 1553B bus, how to use the custom IP core provided by Zynq-7000 in Vivado to realize the design of 1553B bus interface scheme and improve the interface performance, simplify applications and reduce costs.