Registration is a prerequisite process for the multi-sensor networking system to estimate and correct systematic errors accurately. The classical registration algorithm such as least square algorithm (LS), generalized least square algorithm (GLS), recursive least square algorithm (RLS) and corrected exact method algorithm (CEX) are compared. An extended registration model is proposed to solve the registration problem for the multi-sensor networking system. The convergence of algorithm in real-time registration is difficult to judged, so this work provides a judgment method. The result shows the performance of such registration algorithms and confirmed the validity of extended registration model and convergence judgment method, the guidance is given in the practical choice of registration algorithms.