With the research of communication and signal processing algorithms, suitable and effective modulationalgorithms can ensure the quality of transmitted signals, and further improve the performance and indicators of communicationsystems. The principle of Minimum Shift Keying (MSK) modulation is introduced, a method of 16 times sampling MSK modulationis designed, and the design on Xilinx Field Programmable Gate Array (FPGA) is implemented. Vivado Simulation is used to simulatethe modulation process, through a lot of tests and Matlab. The correctness of the design and implementation is verified bycomparison of the calculation results, which provides a guarantee for the effective transmission of communication signals.