With the diversification and complexity of space missions, the on-board electronic equipment demands more and more processor resources, which leads to more and more complex chips being applied to satellite platforms. Due to the complexity of space radiation environment, the impact on complex integrated cricuits is particularly obvious. The anti-radiation reinforcement design of System on Chip (SOC) chip in space radiation environment is designed to improve the reliability of SOC chip in orbit operation, solve the problem that SOC chip is susceptible to radiation, and thus improve the reliability of the system.